Syrian and Afghan refugees are believed to be among those due to be on the first flight.
The Home Office says the plan will help crack down on people smugglers and deter small boat crossings.
“We feel that this issue is another ‘Windrush Scandal’ in the making,” said Omar Leon, vice-chair of Caribbean Labour Solidarity.
“The UK Home Office in its current state, has been tearing through communities, terrorising local residents with immigration raids, and in the case of those referred to as the ‘Jamaica 50’, have been detaining scores of Jamaican nationals – who’ve built lives in the UK – at immigration detention centres.
“We stand in full solidarity with all groups who are affected by the Rwanda deal, and all who are organising around this protest, as the issue of deportation has deeply impacted the Caribbean community.“
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Asylum seekers have been offered the option between being sent back to conflict zones in their home countries, or to Rwanda, the Guardian reports.
Announcing the first flight to Rwanda, Home Secretary Priti Patel hailed the plans, saying: “Our world-leading partnership with Rwanda is a key part of our strategy to overhaul the broken asylum system and break the evil people-smugglers’ business model.”
Zita Holbourne, national chair and co-founder of campaign group BARAC UK, a group of black activists campaigning against racism and cuts to public services, said the policy is inhumane and “completely horrific.”
She said: “Some refugees will have fled persecution, climate change and/or conflict on the African continent only to be sent back to the continent. It is a deeply racist and unjust policy disproportionately and impacting black and brown refugees.”
A Home Office spokesperson told The Big Issue:
“Rwanda is a safe and stable country, which has been recognised globally for their record in welcoming and integrating migrants and asylum seekers. It will be able to offer a home, stability, and a future for those in need.
“Last year, the UNHCR (United Nations High Commissioner for Refugees) and the EU worked with Rwanda to resettle refugees from Libya there – the UNHCR praised the Rwandan Government for offering a welcoming and safe environment to vulnerable people around the world.
“We are fully committed to working with Rwanda to offer safety to those seeking asylum and ultimately save lives through this innovative, ambitious partnership.”